Remote, online geriatric assessment (GA) is gaining attention in oncology. Most GA domains can be assessed remotely. However, there is limited evidence identifying reliable tools that can be used in lieu of objective measures of physical function, such as grip strength and physical performance during remote, online GA. In this prospective cohort study, we aimed to assess the performance of the SARC-F, a screening questionnaire for sarcopenia, in identifying low grip strength and the Short Physical Performance Battery (SPPB). Additionally, we assessed the satisfaction of clinical staff with using the SARC-F in the clinic.
Materials and Methods
Data were prospectively collected from older adults with cancer of any type and stage who underwent GA in the geriatric oncology clinic of a tertiary cancer centre. Following GA, patients were asked to complete the SARC-F tool. Spearman correlations were performed between objective measures of physical function, SARC-F domains, and SARC-F total score. Additionally, the sensitivity, specificity, positive predictive value, and negative predictive value were assessed to evaluate the performance of SARC-F to detect low grip strength and SPPB.
Eighty (n = 80) older adults (mean age: 80 years) with cancer completed the SARC-F. A positive SARC-F was found in 31.3% of the cohort. Moderate correlations were found between the SPPB per point and Assistance in walking (r = −0.69), as well as the SPPB per point and total SARC-F score (r = −0.66). SARC-F exhibited moderate sensitivity in identifying low grip strength using the Foundation for the National Institutes of Health (FNIH) criteria (sensitivity: 64.3%) or the Sarcopenia Definitions and Outcomes Consortium (SDOC) criteria (sensitivity: 40.4%). However, specificity was high (>75%) regardless of the criteria applied. Similarly, moderate sensitivity (52.2%), but excellent specificity (97.1%) was found for SPPB. When low grip strength per FNIH was combined with low SPPB, SARC-F demonstrated high sensitivity (80%) and specificity (75.7%).
SARC-F exhibited promising performance in identifying low grip strength per FNIH and low SPPB combined. To definitively assess the performance of the SARC-F in detecting low grip strength and SPPB, larger studies are warranted.
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- Geriatric oncology research to improve clinical care.Nat Rev Clin Oncol. 2012; 9: 571-578
- Geriatric assessment is associated with completion of chemotherapy, toxicity, and survival in older adults with cancer.J Geriatr Oncol. 2013; 4: 227-234
- Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.J Clin Oncol. 2011; 29: 3457-3465
- Practical assessment and Management of Vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology summary.J Oncol Pract. 2018; 14: 442-446
- International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer.J Clin Oncol. 2014; 32: 2595-2603
- The assessment and management of older cancer patients: a SIOG surgical task force survey on surgeons’ attitudes.Eur J Surg Oncol. 2016; 42: 297-302
- Electronic rapid fitness assessment: a novel tool for preoperative evaluation of the geriatric oncology patient.J Natl Compr Canc Netw. 2017; 15: 172-179
- Electronic geriatric assessment: is it feasible in a multi-institutional study that included a notable proportion of older African American patients? (Alliance A171603).JCO Clin Cancer Inform. 2021; 5: 435-441
- The development of geriatric assessment and intervention guidelines for an online geriatric assessment tool: a Canadian modified Delphi panel study.Curr Oncol. 2022; 29: 853-868
- The impact of pre-treatment muscle strength and physical performance on treatment modification in older adults with cancer following comprehensive geriatric assessment.Age Ageing. 2022; 51
- Physical performance measures for predicting outcome in cancer patients: a systematic review.Acta Oncol. 2016; 55: 1386-1391
- Physical function and all-cause mortality in older adults diagnosed with cancer: a systematic review and meta-analysis.J Gerontol A Biol Sci Med Sci. 2021; 76: 1447-1453
- Correlation between the short physical performance battery (SPPB) and virtual SPPB (vSPPB) among older adults with myeloid malignancies.J Geriatr Oncol. 2021; 12: S15
- Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer.J Geriatr Oncol. 2015; 6: 433-441
- SARC-F: a simple questionnaire to rapidly diagnose sarcopenia.J Am Med Dir Assoc. 2013; 14: 531-532
- Sarcopenia: revised European consensus on definition and diagnosis.Age Ageing. 2019; 48: 601
- Reliability and concurrent validity of the SARC-F and its modified versions: a systematic review and Meta-analysis.J Am Med Dir Assoc. 2021; 22 ([e16]): 1864-1876
- SARC-F for screening of sarcopenia among older adults with cancer.Cancer. 2021; 127: 1469-1475
- Objective measures of physical function and their association with cognitive impairment in older adults with cancer prior to treatment.J Geriatr Oncol. 2022; 13: 1141-1148
- The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates.J Gerontol A Biol Sci Med Sci. 2014; 69: 547-558
- Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis.J Am Geriatr Soc. 2020; 68: 1429-1437
- Short physical performance battery and all-cause mortality: systematic review and meta-analysis.BMC Med. 2016; 14: 215
- Using the short physical performance battery to screen for frailty in young-old adults with distinct socioeconomic conditions.Geriatr Gerontol Int. 2013; 13: 421-428
- Rapid screening for sarcopenia.J Cachexia Sarcopenia Muscle. 2015; 6: 312-314
- Statistical methodology: I. incorporating the prevalence of disease into the sample size calculation for sensitivity and specificity.Acad Emerg Med. 1996; 3: 895-900
- Associations of low handgrip strength with cancer mortality: a multicentre observational study.J Cachexia Sarcopenia Muscle. 2020; 11: 1476-1486
- Short physical performance battery, usual gait speed, grip strength and vulnerable elders survey each predict functional decline among older women with breast cancer.J Geriatr Oncol. 2017; 8: 356-362
- Sarcopenia definitions and outcomes consortium (SDOC) criteria are strongly associated with malnutrition, depression, falls, and fractures in high-risk older persons.J Am Med Dir Assoc. 2021; 22: 741-745
Published online: January 17, 2023
Accepted: December 23, 2022
Received in revised form: December 19, 2022
Received: October 11, 2022
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