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Selection of chemotherapy for older patients with pancreatic cancer based on geriatric assessment

Published:September 14, 2022DOI:https://doi.org/10.1016/j.jgo.2022.09.005
      There is no established method to select chemotherapy regimens for older patients with unresectable or recurrent pancreatic cancer. In the case of chemotherapy for lung cancer, a phase III study compared regimen selection using geriatric assessment (GA) with conventional regimen selection based on age and performance status and revealed that GA-based regimen selection reduced the number of adverse events experienced without affecting the treatment efficacy [
      • Corre R.
      • Greillier L.
      • Le Caer H.
      • Audigier-Valette C.
      • Baize N.
      • Berard H.
      • et al.
      Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non-small-cell lung cancer: the phase III randomized ESOGIA-GFPC-GECP 08-02 study.
      ]. We therefore hypothesized that GA could help to optimize treatment selection for older patients with pancreatic cancer. In this prospective study to validate treatment allocation based on GA, older patients with pancreatic cancer were evaluated with GA and, according to the results, a combination of gemcitabine and nanoparticle albumin-bound paclitaxel (GnP), which is the standard of care for younger patients, gemcitabine monotherapy (Gem), or best supportive care (BSC) was selected.
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