Colorectal cancer is the third most frequent cancer worldwide and the fourth most
common cause of cancer mortality [
[1]
]. The average age of patients with colorectal cancer in Western countries is around
70 years old [
[2]
]. Surgery is the current gold standard for treating early-stage colon cancer, with
adjuvant chemotherapy (ACT) in most cases to improve cure rates [
[3]
]. The goal of ACT in patients with colon cancer is to increase the likelihood of
cure while minimizing the risk of toxicity. The ACT is the standard of care in stage
III colon cancer [
[4]
], while in stage II disease, additional clinical risk factors are used to optimize
patient selection for adjuvant treatment [
[5]
]. Furthermore, the risk of toxicity is an important concern in aiding adjuvant treatment
selection for individual patients.Keywords
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Article info
Publication history
Published online: August 26, 2022
Accepted:
August 22,
2022
Received in revised form:
August 17,
2022
Received:
July 8,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
