Over the last 30 years, the evolution of multimodal therapy for locally advanced rectal
cancer (LARC) using neoadjuvant chemoradiotherapy and total mesorectal excision has
resulted in substantial reductions in rates of local recurrence. [
[1]
] However, this success has not been paralleled by a reduction in distant recurrence
with metastases developing in approximately a third of patients, resulting in death
in most cases. [
[1]
,
[2]
]Keywords
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Article info
Publication history
Published online: July 23, 2022
Accepted:
July 18,
2022
Received in revised form:
July 14,
2022
Received:
June 13,
2022
Identification
Copyright
© 2022 Published by Elsevier Ltd.
