The American Society of Hematology (ASH) has recently promoted efforts to advance
the intersection of hematology and aging by sponsoring an annual Scientific Friday
Workshop on Hematology and Aging [
]. Hematologic disorders, both malignant and benign, are highly prevalent among older
adults [
2
,
3
,
4
]. Despite the disproportionate burden of hematologic disease among older adults [
2
,
3
,
4
,
5
], research studying the implications of age across the translational spectrum remains
limited older adults understudied [
6
,
7
,
8
]. The lack of pre-clinical aging models, dearth of translational efforts across diseases,
and under-enrollment of older adults in clinical trials result in substantial gaps
in knowledge. Understanding the interface of human aging and hematologic disorders
in a growing population of older adults is warranted. Here we outline the progress
to date spearheaded by the ASH community dedicated to hematology and aging.To read this article in full you will need to make a payment
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References
- ([ASoHAAMFSWRf])
- Krapcho M. Miller D. Bishop K. Kosary C.L. Yu M. Ruhl J. Tatalovich Z. Mariotto A. Lewis D.R. Chen H.S. Feuer E.J. Cronin K.A. SEER Cancer Statistics Review, 1975–2014. National Cancer Institute, Bethesda, MDJanuary 2018 ([https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER web site])
- Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005.Public Health Nutr. 2009; 12: 444-454
- Future of cancer incidence in the United States: burdens upon an aging, changing nation.J Clin Oncol. 2009; 27: 2758-2765
- Elderly task force in hematology ES. Aging and blood disorders: new perspectives, new challenges.Haematologica. 2015; 100: 415-417
- Enrollment of Older Adults in Clinical Trials Evaluating Patients with Hematologic Malignancies – the Food and Drug Administration (FDA).ASH, 2017 ([Abstract 861])
- Are ongoing trials on hematologic malignancies still excluding older subjects?.Haematologica. 2013; 98: 997-1000
- Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health Clinical Trial Registry.Oncologist. 2014; 19: 1069-1075
- ([ASoHAafhrRf])
- Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.N Engl J Med. 2014; 371: 2477-2487
- Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.Blood. 2016; 127: 893
- The hallmarks of aging.Cell. 2013; 153: 1194-1217
- Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.Cell Stem Cell. 2013; 13: 285-299
- Epigenetic control of stem cell potential during homeostasis, aging, and disease.Cell Stem Cell. 2015; 16: 613-625
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.Nat Med. 2016; 22: 78-83
- Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.Nature. 2015; 520: 549-552
- The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells.Cell Cycle. 2015; 14: 2734-2742
- Frailty and the management of hematologic malignancies.Blood. 2018; 131: 515-524
- Physiologic frailty in nonelderly hematopoietic cell transplantation patients: results from the bone marrow transplant survivor study.JAMA Oncol. 2016; 2: 1277-1286
- Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005.Public Health Nutr. 2009; 12: 444-454
- Unexplained Anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral Anemia clinic.J Gerontol A Biol. 2011; 66: 925-932
- Anemia at older age: etiologies, clinical implications, and management.Blood. 2018; 131: 505-514
- Incidence and mortality of venous thrombosis: a population-based study.J Thromb Haemost. 2007; 5: 692-699
- Venous thrombosis in the elderly: more questions than answers.Blood. 2007; 110: 3097-3101
- Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study.Arch Intern Med. 1998; 158: 585-593
- Venous thrombosis in the elderly: incidence, risk factors and risk groups.J Thromb Haemost. 2010; 8: 2105-2112
- Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report.Chest. 2016; 149: 315-352
- ([ASoHACPGRf])
- The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span.Cold Spring Harb Perspect Med. 2016; 6a025163
Article info
Publication history
Published online: May 12, 2018
Accepted:
April 25,
2018
Received:
April 10,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.