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Short survey| Volume 9, ISSUE 4, P287-290, July 2018

A call to action in hematologic disorders: A report from the ASH scientific workshop on hematology and aging

      The American Society of Hematology (ASH) has recently promoted efforts to advance the intersection of hematology and aging by sponsoring an annual Scientific Friday Workshop on Hematology and Aging [ ]. Hematologic disorders, both malignant and benign, are highly prevalent among older adults [
      • Howlader N.N.A.
      ,
      • McLean E.
      • Cogswell M.
      • Egli I.
      • Wojdyla D.
      • de Benoist B.
      Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005.
      ,
      • Smith B.D.
      • Smith G.L.
      • Hurria A.
      • Hortobagyi G.N.
      • Buchholz T.A.
      Future of cancer incidence in the United States: burdens upon an aging, changing nation.
      ]. Despite the disproportionate burden of hematologic disease among older adults [
      • Howlader N.N.A.
      ,
      • McLean E.
      • Cogswell M.
      • Egli I.
      • Wojdyla D.
      • de Benoist B.
      Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005.
      ,
      • Smith B.D.
      • Smith G.L.
      • Hurria A.
      • Hortobagyi G.N.
      • Buchholz T.A.
      Future of cancer incidence in the United States: burdens upon an aging, changing nation.
      ,
      • Bron D.
      • Ades L.
      • Fulop T.
      • Goede V.
      • Stauder R.
      Elderly task force in hematology ES. Aging and blood disorders: new perspectives, new challenges.
      ], research studying the implications of age across the translational spectrum remains limited older adults understudied [
      • Kanapuru Bindu
      • Singh Harpreet
      • Myers Adrian
      • Beaver Julia A.
      • Kwitkowski Virginia Elaine
      • Farrell Ann T.
      • et al.
      Enrollment of Older Adults in Clinical Trials Evaluating Patients with Hematologic Malignancies – the Food and Drug Administration (FDA).
      ,
      • Cherubini A.
      • Pierri F.
      • Gasperini B.
      • et al.
      Are ongoing trials on hematologic malignancies still excluding older subjects?.
      ,
      • Hamaker M.E.
      • Stauder R.
      • van Munster B.C.
      Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health Clinical Trial Registry.
      ]. The lack of pre-clinical aging models, dearth of translational efforts across diseases, and under-enrollment of older adults in clinical trials result in substantial gaps in knowledge. Understanding the interface of human aging and hematologic disorders in a growing population of older adults is warranted. Here we outline the progress to date spearheaded by the ASH community dedicated to hematology and aging.
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