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Measurement of gait speed in older adults to identify complications associated with frailty: A systematic review

  • Frederic Pamoukdjian
    Correspondence
    Corresponding author at: Unité de coordination en oncogériatrie (UCOG) bâtiment Larey A, 1er étage, hôpital Avicenne (HUPSSD, APHP), 125 rue de Stalingrad, 93000 Bobigny, France. Tel.: +33 1 48 95 70 35; fax: +33 1 48 95 70 36.
    Affiliations
    Unité de coordination en oncogériatrie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France

    Service de médecine gériatrique, hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France
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  • Elena Paillaud
    Affiliations
    Département de gériatrie, unité d'oncologie gériatrique, hôpital Henri-Mondor, APHP, F94000, Créteil, France

    Université Paris Est, A-TVB DHU, Clinical Epidemiology of Ageing (CEpiA) EA4393, F94010, Créteil, France
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  • Laurent Zelek
    Affiliations
    Service d'oncologie médicale, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France
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  • Marie Laurent
    Affiliations
    Département de gériatrie, unité d'oncologie gériatrique, hôpital Henri-Mondor, APHP, F94000, Créteil, France

    Université Paris Est, A-TVB DHU, Clinical Epidemiology of Ageing (CEpiA) EA4393, F94010, Créteil, France
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  • Vincent Lévy
    Affiliations
    Unité de Recherche Clinique et Centre de Recherche Clinique, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France
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  • Thierry Landre
    Affiliations
    Unité de coordination en oncogériatrie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France
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  • Georges Sebbane
    Affiliations
    Unité de coordination en oncogériatrie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France

    Service de médecine gériatrique, hôpital Avicenne, Hôpitaux Universitaires de Paris Seine Saint Denis (HU PSSD, APHP), Bobigny (93000), France
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Published:September 08, 2015DOI:https://doi.org/10.1016/j.jgo.2015.08.006

      Abstract

      Several frailty screening tests in older cancer patients were developed but their statistical performance is low. We aimed to assess whether measurement of usual gait speed (GS) alone could be used as a frailty screening test in older cancer patients. This systematic review was conducted on “pub med” between 1984 and 2014 and included reviews and original studies. Eligibility criteria were: GS over a short distance, alone or included in composite walking tests (Timed Get Up and Go test: TGUG, Short Physical Performance Battery: SPPB) in older people (aged 65 and over) living in a community setting and predictive value of GS on medical complications associated with frailty. 46 articles were finally selected. GS alone is consensual and recommended for screening sarcopenia in elderly. A slow GS is predictive of early death, disability, falls and hospitalization/institutionalization in older people living in a community setting. GS alone is comparable to composite walking tests that do not provide additional information on the medical complications associated with frailty. Despite few studies in geriatric oncology, GS seems to predict overall survival and disability. We suggest GS over 4 m (at a threshold of 1 m/s) as a new frailty screening test in older cancer patients (65 and over) to guide the implementation of a comprehensive geriatric assessment during the initial management phase or during follow-up. Prospective cohort studies are needed to validate this algorithm and compare it with other screening tool.

      Keywords

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      References

        • Walston J.
        • Hadley E.C.
        • Ferrucci L.
        • Guralnik J.M.
        • Newman A.B.
        • Studenski S.A.
        • et al.
        Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National institute on aging research conference on frailty in older adults.
        J Am Geriatr Soc. 2006 Jun; 54: 991-1001
        • Fried L.P.
        • Tangen C.M.
        • Walston J.
        • Newman A.B.
        • Hirsch C.
        • Gottdiener J.
        • et al.
        Frailty in older adults: evidence for a phenotype.
        J Gerontol A Biol Sci Med Sci. 2001 Mar; 56: M146-M156
        • Gill T.M.
        • Gahbauer E.A.
        • Allore H.G.
        • Han L.
        Transitions between frailty states among community-living older persons.
        Arch Intern Med. 2006 Feb 27; 166: 418-423
        • Rockwood K.
        • Song X.
        • MacKnight C.
        • Bergman H.
        • Hogan D.B.
        • McDowell I.
        • et al.
        A global clinical measure of fitness and frailty in elderly people.
        CMAJ. 2005 Aug 30; 173: 489-495
        • Hamaker M.E.
        • Jonker J.M.
        • de Rooij S.E.
        • Vos A.G.
        • Smorenburg C.H.
        • van Munster B.C.
        Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review.
        Lancet Oncol. 2012 Oct; 13: e437-e444
        • Bellera C.A.
        • Rainfray M.
        • Mathoulin-Pélissier S.
        • Mertens C.
        • Delva F.
        • Fonck M.
        • et al.
        Screening older cancer patients: first evaluation of the G-8 geriatric screening tool.
        Ann Oncol. 2012 Aug; 23: 2166-2172
        • Abellan van Kan G.
        • Rolland Y.
        • Houles M.
        • Gillette-Guyonnet S.
        • Soto M.
        • Vellas B.
        The assessment of frailty in older adults.
        Clin Geriatr Med. 2010 May; 26: 275-286
        • Abellan van Kan G.
        • Rolland Y.
        • Bergman H.
        • Morley J.E.
        • Kritchevsky S.B.
        • Vellas B.
        The I.A.N.A Task Force on frailty assessment of older people in clinical practice.
        J Nutr Health Aging. 2008 Jan; 12: 29-37
        • Abellan van Kan G.
        • Rolland Y.
        • Andrieu S.
        • Bauer J.
        • Beauchet O.
        • Bonnefoy M.
        • et al.
        Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an international academy on nutrition and aging (IANA) task force.
        J Nutr Health Aging. 2009 Dec; 13: 881-889
        • Wildiers H.
        • Heeren P.
        • Puts M.
        • Topinkova E.
        • Janssen-Heijnen M.L.
        • Extermann M.
        • et al.
        International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer.
        J Clin Oncol. 2014 Aug 20; 32: 2595-2603
        • Soubeyran P.
        • Fonck M.
        • Blanc-Bisson C.
        • Blanc J.F.
        • Ceccaldi J.
        • Mertens C.
        • et al.
        Predictors of early death risk in older patients treated with first-line chemotherapy for cancer.
        J Clin Oncol. 2012 May 20; 30: 1829-1834
        • Klepin H.D.
        • Geiger A.M.
        • Tooze J.A.
        • Kritchevsky S.B.
        • Williamson J.D.
        • Ellis L.R.
        • et al.
        Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia.
        Blood. 2013 May 23; 121: 4287-4294https://doi.org/10.1182/blood-2012-12-471680
        • Moher D.
        • Liberati A.
        • Tetzlaff J.
        • Altman D.G.
        PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
        PLoS Med. 2009 Jul 21; 6e1000097https://doi.org/10.1371/journal.pmed.1000097
        • Von Elm E.
        • Altman D.G.
        • Egger M.
        • Pocock S.J.
        • Gotzsche P.C.
        • Vanderbroucke J.P.
        • et al.
        The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies.
        Int J Surg. 2014 Dec; 12: 1495-1499
        • Kressig R.W.
        • Beauchet O.
        Guidelines for clinical applications of spatio-temporal gait analysis in older adults.
        Aging Clin Exp Res. 2006 Apr; 18: 174-176
        • Kim M.J.
        • Yabushita N.
        • Kim M.K.
        • Nemoto M.
        • Seino S.
        • Tanaka K.
        Mobility performance tests for discriminating high risk of frailty in community-dwelling older women.
        Arch Gerontol Geriatr. 2010 Sep-Oct; 51: 192-198
        • Fielding R.A.
        • Vellas B.
        • Evans W.J.
        • Bhasin S.
        • Morley J.E.
        • Newman A.B.
        • et al.
        Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences.
        J Am Med Dir Assoc. 2011 May; 12: 249-256
        • Cruz-Jentoft A.J.
        • Baeyens J.P.
        • Bauer J.M.
        • Boirie Y.
        • Cederholm T.
        • Landi F.
        • et al.
        Sarcopenia: European consensus on definition and diagnosis.
        Age Ageing. 2010 Jul; 39: 412-423
        • Studenski S.
        • Perera S.
        • Patel K.
        • Rosano C.
        • Faulkner K.
        • Inzitari M.
        • et al.
        Gait speed and survival in older adults.
        JAMA. 2011 Jan 5; 305: 50-58
        • Cooper R.
        • Kuh D.
        • Hardy R.
        Mortality Review Group; FALCon and HALCyon Study Teams. Objectively measured physical capability levels and mortality: systematic review and meta-analysis.
        BMJ. 2010 Sep 9; 341: c4467
        • Woo J.
        • Ho S.C.
        • Yu A.L.
        Walking speed and stride length predicts 36 months dependency, mortality, and institutionalization in Chinese aged 70 and older.
        J Am Geriatr Soc. 1999 Oct; 47: 1257-1260
        • Markides K.S.
        • Black S.A.
        • Ostir G.V.
        • Angel R.J.
        • Guralnik J.M.
        • Lichtenstein M.
        Lower body function and mortality in Mexican American elderly people.
        J Gerontol A Biol Sci Med Sci. 2001 Apr; 56: M243-M247
        • Perera S.
        • Studenski S.
        • Chandler J.M.
        • Guralnik J.M.
        Magnitude and patterns of decline in health and function in 1 year affect subsequent 5-year survival.
        J Gerontol A Biol Sci Med Sci. 2005 Jul; 60: 894-900
        • Cesari M.
        • Kritchevsky S.B.
        • Penninx B.W.
        • Nicklas B.J.
        • Simonsick E.M.
        • Newman A.B.
        • et al.
        Prognostic value of usual gait speed in well-functioning older people—results from the Health, Aging and Body Composition Study.
        J Am Geriatr Soc. 2005 Oct; 53: 1675-1680
        • Ostir G.V.
        • Kuo Y.F.
        • Berges I.M.
        • Markides K.S.
        • Ottenbacher K.J.
        Measures of lower body function and risk of mortality over 7 years of follow-up.
        Am J Epidemiol. 2007 Sep 1; 166: 599-605
        • Hardy S.E.
        • Perera S.
        • Roumani Y.F.
        • Chandler J.M.
        • Studenski S.A.
        Improvement in usual gait speed predicts better survival in older adults.
        J Am Geriatr Soc. 2007 Nov; 55: 1727-1734
        • Cesari M.
        • Onder G.
        • Zamboni V.
        • Manini T.
        • Shorr R.I.
        • Russo A.
        • et al.
        Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study.
        BMC Geriatr. 2008 Dec; 8: 34
        • Cesari M.
        • Pahor M.
        • Marzetti E.
        • Zamboni V.
        • Colloca G.
        • Tosato M.
        • et al.
        Self-assessed health status, walking speed and mortality in older Mexican-Americans.
        Gerontology. 2009; 55: 194-201
        • Cesari M.
        • Pahor M.
        • Lauretani F.
        • Zamboni V.
        • Bandinelli S.
        • Bernabei R.
        • et al.
        Skeletal muscle and mortality reslts from the InCHIANTI study.
        J Gerontol A Biol Sci Med Sci. 2009 Mar; 64: 377-384
        • Cesari M.
        • Kritchevsky S.B.
        • Newman A.B.
        • Simonsick E.M.
        • Harris T.B.
        • Penninx B.W.
        • et al.
        Health, Aging and Body Composition Study. Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study.
        J Am Geriatr Soc. 2009 Feb; 57: 251-259
        • White D.K.
        • Neogi T.
        • Nevitt M.C.
        • Peloquin C.E.
        • Zhu Y.
        • Boudreau R.M.
        • et al.
        Trajectories of gait speed predict mortality in well-functionning older adults: the health, aging and body composition study.
        J Gerontol A Biol Sci Med Sci. 2013 Apr; 68: 456-464
        • Toots A.
        • Rosendahl E.
        • Lundi-Olsson L.
        • Nordström P.
        • Gustafson Y.
        • Littbrand H.
        Usual gait speed independently predicts mortality in very old people: a population-based study.
        J Am Dir Assoc. 2013 Jul; 14 ([e1-6]): 529
        • Vermeulen J.
        • Neyens J.C.
        • van Rossum E.
        • Spreeuwenberg M.D.
        • de Witte L.P.
        Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review.
        BMC Geriatr. 2011 Jul 1; 11: 33https://doi.org/10.1186/1471-2318-11-33
        • Seino S.
        • Yabushita N.
        • Kim M.J.
        • Nemoto M.
        • Jung S.
        • Osuka Y.
        • et al.
        Comparison of a combination of upper extremity performance measures and usual gait speed alone for discriminating upper extremity functional limitation and disability in older women.
        Arch Gerontol Geriatr. 2012 Sep-Oct; 55: 486-491
        • Ostir G.V.
        • Markides K.S.
        • Black S.A.
        • Goodwin J.S.
        Lower body functioning as a predictor of subsequent disability among older Mexican Americans.
        J Gerontol A Biol Sci Med Sci. 1998 Nov; 53: M491-M495
        • Shinkai S.
        • Watanabe S.
        • Kumagai S.
        • Fujiwara Y.
        • Amano H.
        • Yoshida H.
        • et al.
        Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population.
        Age Ageing. 2000 Sep; 29: 441-446
        • Onder G.
        • Penninx B.W.
        • Ferrucci L.
        • Fried L.P.
        • Guralnik J.M.
        • Pahor M.
        Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study.
        J Gerontol A Biol Sci Med Sci. 2005 Jan; 60: 74-79
        • Wennie Huang W.N.
        • Perera S.
        • VanSwearingen J.
        • Studenski S.
        Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults.
        J Am Geriatr Soc. 2010 May; 58: 844-852
        • Seidel D.
        • Brayne C.
        • Jagger C.
        Limitations in physical functioning among older people as a predictor of subsequent disability in instrumental activities of daily living.
        Age Ageing. 2011 Jul; 40: 463-469
        • Deshpande N.
        • Metter E.J.
        • Guralnik J.
        • Bandinelli S.
        • Ferrucci L.
        Predicting 3-year incident mobility disability in middle-aged and older adults using physical performance tests.
        Arch Phys Med Rehabil. 2013 May; 94: 994-997
        • Stenholm S.
        • Guralnik J.M.
        • Bandinelli S.
        • Ferrucci L.
        The prognostic value of repeated measures of lower extremity performance: should we measure more than once?.
        J Gerontol A Biol Sci Med Sci. 2014 Jul; 69: 894-899
        • Shimada H.
        • Tiedemann A.
        • Lord S.R.
        • Suzukawa M.
        • Makizako H.
        • Kobayashi K.
        • et al.
        Physical factors underlying the association between lower walking performance and falls in older people: a structural equation model.
        Arch Gerontol Geriatr. 2011 Sep-Oct; 53: 131-134
        • Biderman A.
        • Cwikel J.
        • Fried A.V.
        • Galinsky D.
        Depression and falls among community dwelling elderly people: a search for common risk factors.
        J Epidemiol Community Health. 2002 Aug; 56: 631-636
        • Montero-Odasso M.
        • Schapira M.
        • Soriano E.R.
        • Varela M.
        • Kaplan R.
        • Camera L.A.
        • et al.
        Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older.
        J Gerontol A Biol Sci Med Sci. 2005 Oct; 60: 1304-1309
        • Shimada H.
        • Suzukawa M.
        • Tiedemann A.
        • Kobayashi K.
        • Yoshida H.
        • Suzuki T.
        Which neuromuscular or cognitive test is the optimal screening tool to predict falls in frail community-dwelling older people?.
        Gerontology. 2009; 55: 532-538
        • Verghese J.
        • Holtzer R.
        • Lipton R.B.
        • Wang C.
        Quantitative gait markers and incident fall risk in older adults.
        J Gerontol A Biol Sci Med Sci. 2009 Aug; 64: 896-901
        • Kelsey J.L.
        • Berry S.D.
        • Procter-Gray E.
        • Quach L.
        • Nguyen U.S.
        • Li W.
        • et al.
        Indoor and outdoor falls in older adults are different: the maintenance of balance, independent living, intellect, and Zest in the Elderly of Boston Study.
        J Am Geriatr Soc. 2010 Nov; 58: 2135-2141
        • Callisaya M.L.
        • Blizzard L.
        • Schmidt M.D.
        • Martin K.L.
        • McGinley J.L.
        • Sanders L.M.
        • et al.
        Gait, gait variability and the risk of multiple incident falls in older people: a population-based study.
        Age Ageing. 2011 Jul; 40: 481-487
        • Quach L.
        • Galica A.M.
        • Jones R.N.
        • Procter-Gray E.
        • Manor B.
        • Hannan M.T.
        • et al.
        The nonlinear relationship between gait speed and falls: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study.
        J Am Geriatr Soc. 2011 Jun; 59: 1069-1073
        • Kelsey J.L.
        • Procter-Gray E.
        • Hannan M.T.
        • Li W.
        Heterogeneity of falls among older adults: implications for public health prevention.
        Am J Public Health. 2012 Nov; 102: 2149-2156
        • Muraki S.
        • Akune T.
        • Oka H.
        • Ishimoto Y.
        • Nagata K.
        • Yoshida M.
        • et al.
        Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: a longitudinal cohort study.
        Osteoporos Int. 2013 Feb; 24: 459-466
        • Studenski S.
        • Perera S.
        • Wallace D.
        • Chandler J.M.
        • Duncan P.W.
        • Rooney E.
        • et al.
        Physical performance measures in the clinical setting.
        J Am Geriatr Soc. 2003 Mar; 51: 314-322
        • Cawthon P.M.
        • Fox K.M.
        • Gandra S.R.
        • Delmonico M.J.
        • Chiou C.F.
        • Anthony M.S.
        • et al.
        Health, Aging and Body Composition Study. Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?.
        J Am Geriatr Soc. 2009 Aug; 57: 1411-1419
        • Bouillon K.
        • Sabia S.
        • Jokela M.
        • Gale C.R.
        • Singh-Manoux A.
        • Shipley M.J.
        • et al.
        Validating a widely used measure of frailty: are all sub-components necessary? Evidence from the Whitehall II cohort study.
        Age (Dordr). 2013 Aug; 35: 1457-1465
        • Seino S.
        • Kim M.J.
        • Yabushita N.
        • Nemoto M.
        • Jung S.
        • Osuka Y.
        • et al.
        Is a composite score of physical performance measures more useful than usual gait speed alone in assessing functional status?.
        Arch Gerontol Geriatr. 2012 Sep-Oct; 55: 392-398
        • Viccaro L.J.
        • Perera S.
        • Studenski S.A.
        Is timed up and go better than gait speed in predicting health, function, and falls in older adults.
        J Am Geriatr Soc. 2011 May; 59: 887-892
        • Guralnik J.M.
        • Ferrucci L.
        • Pieper C.F.
        • Leveille S.G.
        • Markides K.S.
        • Ostir G.V.
        • et al.
        Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery.
        J Gerontol A Biol Sci Med Sci. 2000 Apr; 55: M221-M231
        • Clay C.A.
        • Perera S.
        • Wagner J.M.
        • Miller M.E.
        • Nelson J.B.
        • Greenspan S.L.
        Physical function in men with prostate cancer on androgen deprivation therapy.
        Phys Ther. 2007 Oct; 87: 1325-1333
        • Klepin H.D.
        • Geiger A.M.
        • Tooze J.A.
        • Newman A.B.
        • Colbert L.H.
        • Bauer D.C.
        • et al.
        Health, Aging and Body Composition Study. Physical performance and subsequent disability and survival in older adults with malignancy: results from the health, aging and body composition study.
        J Am Geriatr Soc. 2010 Jan; 58: 76-82
        • Cesari M.
        • Cerullo F.
        • Zamboni V.
        • Di Palma R.
        • Scambia G.
        • Balducci L.
        • et al.
        Functional status and mortality in older women with gynecological cancer.
        J Gerontol A Biol Sci Med Sci. 2013 Sep; 68: 1129-1133
        • Lilamand M.
        • Dumonteil N.
        • Nourhashémi F.
        • Hanon O.
        • Marcheix B.
        • Toulza O.
        • et al.
        Gait speed and comprehensive geriatric assessment: two keys to improve the management of older persons with aortic stenosis.
        Int J Cardiol. 2014 May 15; 173: 580-582